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Aciklovir (Acyclovir)
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Acyclovir

Aciklovir is an antiviral drug, a synthetic nucleoside analogue, that has inhibitory activity (interferes with viral replication) against the herpes viruses, including herpes simplex 1 and 2 (cold sores and genital herpes), varicella-zoster (shingles and chickenpox), and Epstein-Barr virus (mononucleosis). Viruses take over living cells and reproduce themselves, often at the expense of the host cell. The Aciklovir is converted to an active form by the virus itself, and the virus then uses the active form of Aciklovir rather than the nucleoside it normally uses to manufacture DNA, a critical component of viral replication. Incorporation of active Aciklovir into new viral DNA stops the production of the DNA. Virally infected cells absorb more Aciklovir than normal cells and convert more of it to the active form, which prolongs its antiviral activity. The FDA approved Aciklovir in March 1982.

Other names for this medication:
Acyclovir, Abduce, Acic, Aciclobeta, Aciclomed, Aciclostad, Aciclovirum, Acifar, Acihexal, Aciklovir, Acitop, Acivir, Acivirex, Acivision, Acix, Actios, Activir, Acycloguanosine, Acyl, Acyrax, Acyvir, Aklovir, Antivir, Asiviral, Avir, Aviral, Avix, Avorax, Blistex, Cicloferon, Cicloviral, Clinovir, Clirbest, Clopes, Clovate, Clovir, Cusiviral, Cyclomed, Cyclovax, Cyclovex, Cyclovir, Danovir, Declovir, Epsin, Eurovir, Hascovir, Hernovir, Herperax, Herpesil, Herpesin, Herpex, Herpin, Herplex, Heviran, Immunovir, Lisovyr, Lovir, Lovire, Lovrak, Medovir, Menova, Ocuvir, Poviral, Ranvir, Remex, Rexan, Scanovir, Sitavig, Sophivir, Soviclor, Supraviran, Telviran, Uniplex, Vilerm, Viraban, Viralex, Viratac, Viratop, Virest, Virestat, Virex, Virless, Virolex, Viromed, Virosil, Virostatic, Virovir, Virucid, Viruderm, Virustat, Virux, Vivorax, Xiclovir, Xorox, Zevin, Ziverone, Zoral, Zorax, Zoraxin, Zovirax,

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Diagnostic performance and system delay using telemedicine for prehospital diagnosis in triaging and treatment of STEMI. Isoflurane induces both excitatory and inhibitory actions in the cholinergic arousal system. Serum responses, and in some cases intestinal specific antibodies, were measured out to 33 days post-immunization. Since IL-8 is known to be the major inducer of angiogenesis caused by these cells, we examined the ability of fibrin to stimulate IL-8 expression from OSCC cells in vitro. Protection was manifested by a significant decrease in lesion size (as much as a 30-fold reduction) and parasite burden (as much as a 71-fold reduction).

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Complex revival features of rotational wave packets are obtained from the interplay of a molecular rotational distribution and a measured physical observable. To examine consumptive removals for specific prey, diet compositions were summarized into major prey categories, and predatory removals by marine mammal species as well as for total marine mammal consumption were estimated for each prey taxa. These data suggest that acceptance, in particular, may be a construct that explains some variance in maternal distress. To determine whether there is any difference in infection rate at 90 days between trauma operations performed in laminar flow and plenum ventilation, and whether infection risk is altered following the installation of laminar flow (LF).

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The responsiveness of human dental pulp (HDP) cells to bovine plasma FN was investigated. A pessimistic attitude towards the future and low psychosocial functioning predict psychiatric diagnosis among treatment-seeking adolescents.

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Association of increased myocardial contractility and elevated end-diastolic wall tension with short-term myocardial ischemia: a pressure-volume analysis. The present series was comprised of 15 males (one with bladder NA and recurrence in urethra) and 6 females, with ages ranging from 24 to 79 years (mean 55). In countries where routine vital registration data are scarce, Demographic Surveillance Sites (DSS: locally defined populations under longitudinal surveillance for vital events and other characteristics) and Demographic and Health Surveys (DHS: periodic national cluster samples responding to cross-sectional surveys) have become standard approaches for gathering at least some data.

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Overproduction of a penicillin-binding protein is not the only mechanism of penicillin resistance in Enterococcus faecium. Radiation Therapy Plus Anti-Programmed Death Ligand 1 Immunotherapy: A Review on Overall Survival. We, therefore, hypothesized the role of CIZ/NMP4 in B16 melanoma cells that metastasize to bone. It is concluded that ablation of accessory pathways can be accomplished easily and without risk by means of the radiofrequency catheter technique.

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Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices. Because the absolute risk of adverse effects of metoprolol is unknown, the clinical relevance of the CYP2D6 genotype for metoprolol therapy has to be determined in a prospective manner. Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial.

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Effects of different land-use types on soil organic carbon and its prediction in the mountainous areas in the middle reaches of Lancang River Placing medical equipment out of sight leads to reduced feelings of stress in patients. Pubertal assay end points addressed include organ weights, estrous cyclicity, clinical pathology, hormonal assays, and histological evaluation.

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Tracking ability in subjects symptomatic of cumulative trauma disorder: does it relate to disability? The clinical features, pathologic findings, and self-limited course suggested recurrent palmoplantar hidradenitis. Conversely, diminishing cell density, as might occur at a wound front, leads to large, broad collectives with a distinct leader-follower structure. Development of the iliac crest microsurgical free flap has greatly improved the surgical reconstruction of oromandibular defects.

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Mechanism of repression of squamous differentiation marker, SPRR1B, in malignant bronchial epithelial cells: role of critical TRE-sites and its transacting factors. Death was caused by pericardial tamponade combined with bleeding into the pleural cavity. Promoting physical health for people with schizophrenia by reducing disparities in medical and dental care. Thus, ACTH fragments devoid of peripheral endocrine activity reduce pilocarpine-induced epileptiform activity in rats.

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Possible procoagulant roles of microparticles, circulating endothelial cells and endothelial apoptosis, are also discussed. T-cell line-tropic gp120 envelope proteins were at least 10-fold more susceptible to V3 loop proteolytic cleavage by human thrombin, and 1000-fold more susceptible to V3 loop proteolytic cleavage by human mast cell tryptase than macrophage-tropic gp120 envelope proteins. The Snail1 (Snai1) gene promotes epithelial-mesenchymal transitions during development and disease progression, and Snai1 null mouse embryos exhibit defects in gastrulation.

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It is also probable that mitochondria containing monoamine oxidase type B are transported along the axons, but that this enzyme undergoes a change, for example, conformational change, decomposition or removal from the membranes. The glycosylated nature of these proteins was demonstrated by their reactivity with concanavalin A and by selective labeling with the biotin-hydrazide reagent following periodate oxidation.

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Synthesis of 24,28-iminofucosterol and its inhibitory effects on growth and steroid metabolism in the silkworm, Bombyx mori. TaqMan low density array (LDA) is promising for high throughput screening in functional genomics by simultaneously measuring mRNA expression of multiple genes. In the science of microbial pharmacokineticspharmacodynamics (PK-PD), particular antibiotic exposures are related to outcomes such as microbial kill and resistance suppression, which can often be demonstrated in preclinical models.

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Inactivation of CYB5R2 is associated with lymph node metastasis in NPC. Diagnosis and surgical treatment of congenital aortic septal defects. Factors contributing to clinical seizure lateralization in patients with mesial temporal lobe epilepsy. In both cases, the proliferating tubules reacted with keratin 903 and were negative for prostate-specific antigen and prostate acid phosphatase, thereby excluding the diagnosis of prostatic adenocarcinoma.

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Discovery of nonpeptidic small-molecule AP-1 inhibitors: lead hopping based on a three-dimensional pharmacophore model. Threatened miscarriage in general practice: diagnostic value of history taking and physical examination. BDIX male rats were given an intra-hepatic injection of a mixture containing DHDK12 tumor cells and xenogeneic fibroblasts. Ligand blotting assays of kidney membrane preparations fractionated by SDS-PAGE revealed that Sepp1 binds megalin, a lipoprotein receptor localized to the proximal tubule epithelium.

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Leaf-disc assay based on transient over-expression in Nicotiana benthamiana to allow functional screening of candidate effectors from aphids. Determination of PKC isoform-specific protein expression in pulmonary arteries of rats with chronic hypoxia-induced pulmonary hypertension. Improvements compared to previous versions are achieved through adequately chosen data structures that facilitate the efficient handling of symmetric sparse matrices. The accuracy of DSE is influenced by the LV geometric pattern and peak wall stress.

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Identification of characteristic aroma components of Thai fried chili paste. For visual evaluation, different thresholds of band intensity for considering a test as positive were applied.

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Analysis of clr2 mutant strains revealed a major role for Clr2 in mating-type and rDNA silencing, and weaker effects on centromeric silencing. All patients undergoing colorectal resection with curative intent between 1995 and 1999 at a tertiary referral hospital were retrospectively reviewed. On the other hand serial studies in the same subject can be much more informative because the test is normally highly reproducible if conditions are unchanged. This study compares functional outcome of knee arthrodesis following failed primary arthroplasty with that of revision knee arthroplasty in a matched patient group. Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma.

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Our objectives were to quantify the strains and forces sustained by the vertebral artery (VA) in situ during SMT. To test the hypothesis that the missing causal genes in HCM is, in part, because of an oligogenic cause, wherein the pathogenic variants do not cosegregate with the phenotype. Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles.

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Quantitative PCR was used to detect viral replication in MDCC-MSB1 cells, and the viral localization was observed by confocal microscopy. Several of the most common statistical errors and methodological pitfalls that occur in the field of psycho-oncology are discussed, including those that occur at the design, analysis, reporting and conclusion stages.

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In kidney transplantation, the prevalence of hypercholesterolemia as a co-morbidity factor known to affect graft function, is rising due to the increased number of older donors in response to organ shortage as well as to the hyperlipidemic effects of immunosuppressors in recipient. Supporting diagnosis of attention-deficit hyperactive disorder with novelty detection. This is followed by a further phase transition at more negative potentials involving the readsorption of bilayer patches. Intra-articular bipolarradiofrequency thermocoagulation of the thoracic facet joint may be a technically easier and valid method of treating mid back pain of thoracic facet origin.

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Considering the critical role of bcl-2-associated death promoter (BAD) and p53 proteins in DNA damage -induced apoptosis, the aim of this study was to assess the effect of cAMP-elevating agents on these proteins in doxorubicin-treated pre-B acute lymphoblastic leukemia (pre-B ALL) NALM-6 cells.The pre-B ALL cell line NALM-6 was cultured and treated with doxorubicin in combination with or without cAMP-elevating agents forskolin and 3-isobutyl-1-methylxanthine (IBMX). We examined cryptococcal antigenemia as a risk factor for HIV-associated mortality in Indonesia, which is experiencing a rapidly growing HIV epidemic. Both early invasive and in situ adenocarcinoma stained equally intensely with both agents and both antibodies stained diffusely tubal metaplasia, endometrial lined glands, and even occasional areas of normal endocervical mucosa. In contrast with quasi-one-dimensional systems, the resistivity anomaly associated with the CDW transition is strong in the direction perpendicular to the CDW wave vector Q (a axis) and very weak in the CDW wave vector Q direction (c axis). the difference between soda sales tax and the tax on food products generally) and a summary score representing the strength of state laws governing competitive beverages (beverages that compete with the beverages in the federally funded school lunch programme) in US schools.

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Hepatotoxicity of teucrin A also was increased following pretreatment with the inhibitor of glutathione synthesis buthionine sulfoximine. The therapeutic efficacy was determined biochemically by serum total T3, total T4 and TSH levels at baseline and at 4, 8 and 12 weeks during the study period. To rule out the possibility that interhemispheric neuronal communication might contribute to bilateral functional magnetic resonance imaging responses, we compared stimulus-evoked functional magnetic resonance imaging responses to unilateral hindpaw stimulation in acallosal I/LnJ, C57BL/6, and BALB/c mice. The element not stressed in prior early soft palatoplasties is this full-thickness release of the soft palate from its abnormal insertion along the cleft.

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However, it seems likely that dominant negative mutants of promiscuous viral trans-activator proteins, which by definition would repress rather than activate gene expression, should be able to inhibit infectious virus production for a number of different viruses. Most causes can be determined by a careful history focusing on medications, foods, occupation, and family history. Prostate specific antigen (PSA) determinations after radical prostatectomy are valuable in detecting persistent disease. Given the scope of this public health challenge and the importance of prompt treatment and follow-up counseling to reduce future STI/HIV-related risk behavior, we sought to qualitatively explore STI clinic experiences among individuals diagnosed with STIs via public clinics in Rio de Janeiro, Brazil.

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NSAID induced hemodynamic renal failure is characterized by sudden oliguria, often with decreased fractional excretion of sodium, occurring in patients with decreased effective circulating fluid volume or preexisting renal disease. Truncation from or mutation at the 13th amino acid of the N terminus of MinC(Ng) resulted in loss of protein function.

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Here we investigated whether the TLR-3 ligand, polyinosinic:polycytidylic acid (PolyI:C), increased accumulation of one P-gp substrate in the fetus and in the developing fetal brain. In vitro infection of murine macrophages with the SSG-R strain, but not the SSG-S strain, down regulated expression of host gamma-GCS, which would result in a reduction in intramacrophage glutathione (GSH) levels and promote an oxidative intramacrophage environment.

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Night waking among breastfeeding mothers and infants: Conflict, congruence or both? The interaction of B-cells and PCa may serve as the basis for new therapeutic targets. Highly susceptible HLA haplotypes of type 1 diabetes observed in Caucasian patients are not found in Japanese patients, while protective HLA haplotypes are similar. This would seem to indicate that there may be a carcinogenic role for anthophyllite.

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In men, the breast parenchyma is usually only composed of fat, with absence of fibroglandular tissue. In the patients with ALLA, blood hypercoagulation features were found, expressed as increased level of TAT complexes in spite of lack of abnormalities in comprehensive coagulation studies, while in the patients with hernia only increased AT III activity was found.

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Interstitial fluid samples were obtained from the frontal cortex and hippocampus by using in situ brain microdialysis, and serum and CSF were directly sampled. Tumor growth modifications in the vitamin E supplemented animals may be due to changes in T-cell numbers and functions stimulated by vitamin E. Somnofluoroscopy allows examination of the dynamics of airway closure in this disorder and shows the important role of the soft palate in acting as a plug in the oropharynx. Affinity of cholinergic ligands for the partially purified acetylcholine receptor from mammalian skeletal muscle.

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