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Adapin is a dibenzoxepin derivative and tricyclic antidepressant with antipruritic and sedative activities. Adapin blocks the reuptake of norepinephrine and serotonin into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their action leading to sedative effects. Adapin also has antagonistic effects on histamine (H1 and H2), 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is the result mediated through inhibition of histamine receptors.

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The UEBP content was determined by radioligand technique in control liver and at 2, 4, 14 days of liver regeneration and related to the total DNA content as an indicator of cell proliferative activity. To investigate this putative ATF3 function directly, the rat ATF3 protein was compared with v-Jun for its ability to transform primary cultures of chick embryo fibroblasts (CEFs). We demonstrate the efficiency and usefulness of MPHs in simulations of both jittered and switching spike responses to white noise and natural stimuli. Molecular characterization of the transcription termination factor from human mitochondria. Regional differences in compartmental distribution of palmitate in intestine.

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Low hepatitis delta prevalence estimates in the United States are likely biased due to low testing rates. This information could help inform electronic medical record design. Use of multispecies occupancy models to evaluate the response of bird communities to forest degradation associated with logging.

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Vector positions that enhanced calculation of joint force magnitude increased the sensitivity to errors when calculating joint force direction. Adhesion molecules (ICAM-1, VCAM-1, ELAM-1) and their ligands (LFA-1, VLA-4, sLeX) and lymphoid activation markers (MHC class II, IL-2R) were demonstrated in liver biopsies by immunohistochemistry.

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The results of ChIP real-time PCR coincided well with the microarray data. Solitary renal cyst and polycystic kidney associated with renal hypertension Epidermal growth factor suppresses in vitro senescence in the ability of human umbilical vein endothelial cells to proliferate, but not in the ability to produce prostacyclin.

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Nine months after the onset of symptoms, the case was diagnosed as malabsorption syndrome caused by complexed and aggravated infection by Strongyloides stercoralis, Isospora and cytomegalovirus in the small intestine, which were proved by stool examination and duodenal biopsy. Post-implant dosimetry was performed on Day 1 and Day 30 after implantation using computed tomography (CT) imaging. Descriptive study to characterise intraoperative technical error-event patterns in successful laparoscopic procedures. Furthermore, the structural ensemble that we obtained enabled us to rationalize the results of tryptophan fluorescence experiments in the WT protein and a series of mutational variants.

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For a 9-minute period an on-line measurement of the diameter of a retinal branch arteriole was performed. Compared with a traditional balanced design for this trial, it is shown that the optimal design is substantially more efficient. Profiling assay for lipoxygenase products of linoleic and arachidonic acid by gas chromatography-mass spectrometry. Carbon-14 is a particularly interesting radionuclide from the perspective of dose estimation because it mixes readily with stable CO2, and hence enters the food-chain as fundamental biomolecules. Exposure to low-frequency electromagnetic fields--a health hazard?

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These results suggest that flagellin may serve as an effective adjuvant for vaccines targeted to this vulnerable population. Intracellular studies on photoreceptors in the eyes of the giant clam Tridacna give evidence for two types of light-sensitive cells, both of which are hyperpolarized by light. We present FDG PET/CT findings of a 59-year-old woman with left lower limb pain for 1 month. Postoperative monitoring with water-soluble contrast enema appears to be the diagnostic procedure of choice because it is well tolerated, non-invasive and a reliable aid in planning surgical bowel recanalization since no false negative cases were detected clinically after closure of the colostomy.

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The study of comparative energetics offers a valuable way to identify broad ecological principles and assess the functional significance of energetic adaptations during the course of evolution. The validity and clinical relevance of the slight sitagliptin-induced PGLO reduction remains speculative. ESR-measurement of production of oxygen radicals in vivo before and after renal ischaemia in the rabbit. The temporal relationship between these two parameters was variable.

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A fragment of an 18-gauge catheter was inadvertently severed during catheterization of the cephalic vein in a 7-year-old Golden Retriever. Examination of factors dominating the sediment-water diffusion flux of DDT-related compounds measured by passive sampling in an urbanized estuarine bay. May save a life tomorrow--the story of the Kidney Research Unit for Wales Foundation.

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Cancer recurrence and survival associated with dietary patterns in stage III colon cancer. Since estradiol serum level is high in proestrus females and low in diestrus females and in males, these findings suggest that the high physiological level of estradiol decreases temporomandibular joint inflammation. Technical considerations are discussed as well as possible advantages of this approach including decreased blood loss, faster patient recovery and improved visualization.

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Effect of nonsteroidal anti-inflammatory drugs on the microsomal monooxygenase system of rat liver. Using transposase-coding sequences as a hybridization probe, we estimated that there are about 50 MLE sequences in the pea genome. Role of the Fas/Fas ligand system in female reproductive organs: survival and apoptosis. To this, regenerating bone marrow cells of CBA/H mice, obtained 3 days after 2 Gy irradiation, were preincubated 90 min to 5 hr with increasing concentrations of rIL-1ra (5-100 ng/ml). Their predictive ability was compared with a risk stratification model derived from the EMR data.

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Liver diseases are one of the leading causes of mortality in the world. Effects of lipid environment on the light-induced conformational changes of rhodopsin. They give an account of the principles of peroperative and postoperative treatment within the framework of differentiated care.

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The activity of peritoneally sensitized CTL of the mice that were continuously fed with PG-mixed feed was assayed. In the presence of one stimulus, every 30th response produced food and, in the presence of an alternate stimulus, every 10th response produced food, a brief electric shock, or food plus shock. A typical monoclonal IgG dysglobulinemia whether benign (monoclonal gammopathy of undetermined significance, MGUS) or malignant can give rise to peripheral neuropathy by damaging nerves. At 11-14 weeks of gestation, the nasal bone length of chromosomally abnormal fetuses is not significantly different from normal. Determination of the most effective cooling temperature for the prevention of chemotherapy-induced alopecia.

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The development of inhibitory saccadic trajectory deviations correlates with measures of antisaccadic inhibition. Blastoid transformation of tonsil and peripheral blood lymphocytes by stimulation with human skin extract. Understanding normal glial differentiation has potentially far-reaching implications for developing new forms of treatment for patients with glial neoplasms.

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Several studies have attempted to characterize molecular alterations associated with PTSD, but most findings were limited to the investigation of specific cellular markers in the periphery or defined brain regions. BCWH are divided into three groups: lysozymes, autolysins, and virolysins. This method enables us to represent the long-term potentiation (LTP) and the long-term depression (LTD) of hippocampal neuronal plasticity in an integrated simulation model.

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Nanoparticle delivery systems for cancer therapy: advances in clinical and preclinical research. Smoke condensate from two types of cigarette, dissolved in two solvents, has been applied regularly to the backs of mice at each of seven different dose levels. The structure and composition of the extracellular matrix (ECM) has been shown to modulate cell behavior with respect to shape, movement, proliferation, and differentiation. In six patients reported here, the condition was recognized in three because of recurrent upper gastrointestinal hemorrhage and in three during endoscopic evaluation for epigastric pain.

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