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Difluzole (Fluconazole)

Difluzole is a synthetic compound known as a bis-triazole. It was first used in patients 1994/95 and licensed for use in 1990. It went off patent in 2003. It works by inhibiting the production of ergosterol, a central chemical in the cell walls of fungi. The drug is available as a capsule, oral suspension and intravenous infusion. A typical dose for oral thrush is 100mg per day. The typical dose for vaginal thrush is a 150mg per day. For the prevention of fungal infections in leukaemia, doses from 50-400mg per day have been used and studied. Most authorities recommend between 100 and 400mg. For the treatment of candidemia and other serious Candida infections a minimum dose of 400mg per day (after a loading dose of 800mg) is recommended with increased doses in patients on haemofiltration and/or rifampicin (see below). Some authors have suggested that 800mg is superior for candidaemia, but the data is not compelling. For the treatment of cryptococcal meningitis after amphotericin B, a minimum of 400mg per day initially is used until the patient is stable and then typically 200mg per day. Much larger doses e.g. 800-1200mg per day should be used as an alternative primary regimen (preferably with flucytosine) or for patients failing therapy. Larger doses such as 800-1200mg per day have been used for coccidioidal meningitis. Almost all other treatments have been for 100-400mg per day. Reduced doses may be appropriate in severe renal dysfunction.

Other names for this medication:
Fluconazole, Diflucan, Afumix, Afungil, Batacan, Candidin, Diflazon, Difluzol, Difluzole, Dizole, Dofil, Duracan, Efac, Elazor, Exomax, Farzul, Fluc, Flucomed, Flucon, Fluconapen, Fluconazol, Flusenil, Flutec, Fluvin, Fluzol, Fluzole, Fluzone, Forcan, Govazol, Honguil, Ibarin, Kifluzol, Lavisa, Logican, Lucon, Medoflucon, Novacan, Omastin, Ozole, Ponaris, Rifagen, Sacona, Stabilanol, Syscan, Ticamet, Trican, Triflucan, Trizol, Uzol, Varmec, Zemyc, Zolax, Zoldicam, Zolen, Zoloder, Zucon,

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The results are explained by a model of lateral masking (crowding) based on competitive interactions within receptive fields of cortical neurons. The results can provide further basis for the evaluation of cortical changes in the presence of perirolandic lesions. As nitric oxide is a gas, it cannot be stored and has to be synthesized as required.

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Disability examinations: a look at the Social Security Disability Income System. High implantation and pregnancy rates with transfer of human hatching day 6 blastocysts. There were no differences between adult and infant red cell levels.

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The smallest carbon nanotubes with the chiral index (3,3), (4,3), or (5,1) were unambiguously identified for the first time. In the case of H4PVMo11O40, hydrogen released during the grafting reaction reduces the POM. Initially, CSF and lesions are segmented using Parzen window classifier. We have identified two genetic polymorphisms associated with increased sensitivity to Hg.

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Probiotics might ameliorate the dysbiosis of CF gut microbiota, characterized by a high density of Proteobacterial organisms. The practicality of physicians performing thoracoscopy for diagnostic purposes was assessed in 30 patients with pleural effusions of unknown cause. To the best of our knowledge, this study shows for the first time the explicit dependence upon the relative block length and, in turn, upon the nanostructure of the quasi-2D micelles, of the viscoelastic properties of Langmuir monolayers and suggests that molecular weight and intermolecular interactions are not the only parameters governing the polymer conformation and, in turn, the polymer rheology and dynamics in quasi-2D confined systems. Tuberculosis diagnosis: primary health care or emergency medical services? In this review, we detail the safety of NSAIDs in patients with CVD, provide recommendations on their use in specific disease states, and discuss therapeutic alternatives.

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Progress in the pharmaceutical chemistry of antimalarial agents during the last 2 decades Comparison of the primary structure of reconstructed minimal nucleosomes and nucleosomes isolated from the chromatin Either modified-dose or full-dose CHOP chemotherapy for HIV-NHL, delivered with HAART, is effective and tolerable. The routine examination of semen, which includes sperm concentration, motility and morphology, does not identify defects in sperm chromatin structure. The lack of association of genetically predicted milk consumption with bone health, IHD or T2D suggests few beneficial effects but is more consistent with milk promoting adiposity.

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However, in patients at high risk of bleeding or of the complications of bleeding, consideration should be given to performing tonsillectomy at a time of year of lower incidence. Despite prolonged circulatory assistance and an intra-aortic balloon counterpulsation, cardiopulmonary bypass could not be stopped and the patient died. She subsequently developed an abdominal aspergillosis, which required several abdominal explorations and splenectomy as well as 6 months of therapy with liposomal amphotericin B, but survived and in long-term follow-up is in good health, with completed puberty, and has finished school. We present a versatile optofluidic flow manipulation scheme based on plasmonic heating in a random gold nanoisland substrate (Au-NIS).

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Isolation and characterization of the main small heat shock proteins induced in tomato pericarp by thermal treatment. Is it possible to operate a computing device with zero energy expenditure?

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This review summarises some of the very diverse and key roles played by endosomes in generating effective innate and adaptive immune responses. One case detected on operation, with concurrent affection of the adrenal gland, the second one with the symptomatology of occult haemorrhage.

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Management of the pulmonary nodule-shifting paradigms and an opportunity for change. Patients with auricular or orbital defects were treated with prostheses retained by two or three implants. We examined the distribution of the telomeric motifs (TTAGGG)n using fluorescence in situ hybridization (FISH) in 30 species, representing 17 families of squamate reptiles, and compared them with the collected data from another 38 species from literature.

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A literature review aimed at exploring the links between bullying and depression in primary school children uncovered evidence of depression in the children who bully. MKP-1 interferes with lipopolysaccharide-induced toll-like receptor 4 signaling and limits brain damage due to exaggerated microglial reactivity following acute NMDA injury.

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Careful risk stratification by the heart team is required in patients with severe preprocedural RD. Metabolic remodeling and the alteration of related receptors expressions in failing heart The CV-3988 was infused intravenously into one- and two-kidney, one clip hypertensive, deoxycorticosterone-salt hypertensive, adrenal regeneration hypertensive, spontaneously hypertensive, and normotensive control rats. A Novel Sensor for Sensitive and Selective Detection of Iodide Using Turn-on Fluorescence Graphene Quantum Dots/Ag Nanocomposite.

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Partial purification and identification of an immunosuppressive factor in AIDS sera. Intriguingly, only the apex is affected and compensatory basal hypercontractility is seen.

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Diagnostic efficacy of a recombinant cysteine protease of Spirometra erinacei larvae for serodiagnosis of sparganosis. Twelve patients with infantile spasms and hypsarrhythmic EEGs were treated with tetrabenazine, a drug with antiserotonergic and antiadrenergic activity. Pharmacological and kinetic characterization of adrenomedullin 1 and calcitonin gene-related peptide 1 receptor reporter cell lines.

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Integration of biologic agents into routine practice is especially difficult given the breadth of emerging drugs currently or recently in trials. A laboratory worker was inadvertently inoculated with infectious material while passaging amastigotes of Leishmania tropica.

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Static and dynamic tunability of network motifs were defined as the motif ability to respectively attain steady-state or transient outputs in response to pre-defined input stimuli. We sought to determine the effects of exogenous epidermal growth factor (EGF), heparin-binding EGF (HB-EGF), transforming growth factor alpha (TGF-alpha), single-chain precursor hepatocyte growth factor (SC-HGF), double-chain mature HGF (DC-HGF), and keratinocyte growth factor (KGF) on proliferation, motility, and differentiation of first passage cultures of human corneal epithelial cells in serum-free chemically defined medium. Understanding the biology of metastases can help stratify patients into prognostically meaningful categories and tailor treatment regimens for individual patients. These observations have helped us to disentangle the pathophysiology of atherosclerosis. Exposure to low doses of 137cesium and nicotine during postnatal development modifies anxiety levels, learning, and spatial memory performance in mice.

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Role of chemotherapy in the treatment of primary bronchial carcinoma This strain was eradicated after prophylactic use of vancomycin for her nephrectomy. The mean AI was increased significantly in the right lateral temporal cortex, the right and left inferior frontal regions, the left temporal pole, and the right medial temporal cortex. Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.

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The purpose of this study was to compare findings at presentation and surgical outcomes in patients in whom abdominal aortic aneurysms (AAAs) ruptured after endovascular repair and in patients in whom AAAs ruptured before any treatment during a defined period at a single center. Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice. Surface Plasmon Resonance Biosensor Based on Smart Phone Platforms.

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Practice patterns often develop during residency training, therefore an opportunity exists to improve training and practice around referrals. Radiation-induced one-electron reduction of oligodeoxynucleotides possessing disulfide bond. Cytopathic effects typical of CDV infection were observed after three blind passages in Vero cells, yielding a virus titer of 10(4.6) TCID50/mL. This interaction produces lamina-specific connections, but is probably insufficient for the formation of the modality-specific connections.

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The photoinduced bending and unbending behavior of five azobenzene derivatives including azobenzene, 4-hydroxy-azobenzene, 4-((4-hydroxyphenyl)diazenyl)bezoitrile, 4-((4-methoxyph-enyl)diazenyl)phenol, and 4-(phenyldiazenyl)phenol is systematically studied by considering the incident light intensity and the thickness of the coated chromophore layers. Thirteen malignant neoplasms (seven different tumour types) arising in the postnasal space or surrounding soft tissues extended upwards through the skull base into the middle cranial fossa. A detailed analysis of the results in 1974-75 shows clustering of patients with raised aminotransferase levels in about one-fifth of the units but, unlike past outbreaks of hepatitis B, these clusters are not accompanied by clinical hepatitis among staff. Practical remarks regarding the analysis of markers of acute viral hepatitis Marginal sector fractures, which are common in adults, are very rare.

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The role of YDA in other developmental processes was taken into account to highlight possible implications for this pathway in the embryo. Further observations on the distribution and properties of teleost melanin concentrating hormone.

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In both groups of NIDDM and IDDM, the MNCV and SNCV of median nerve were significantly delayed in conduction. We conclude that in long-living GHR-KO mice, GH-resistance does not confer longevity by improved free-radical scavenging in the liver and kidney, suggesting that greater free-radical defenses in other tissues, or altered glucose metabolism may have a more central role in extending the lifespan of these animals.

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Biotransformation of zeranol: disposition and metabolism in the female rat, rabbit, dog, monkey and man. Endothelial cell ICAM-1 upregulation in response to TNF-alpha is mediated in part by reactive oxygen species (ROS) generated by the endothelial membrane-associated NADPH oxidase and occurs maximally after 4 h as the synthesis of new protein is required. Small-for-gestational-age newborns of female refinery workers exposed to nickel. Synthesis, characterization, and reactivity of iron trisamidoamine complexes that undergo both metal- and ligand-centered oxidative transformations.

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Second, universities acting collectively have a strong negotiating position with respect to other players in the biomedical research arena. REPORT OF THE SECTION ON PREVENTIVE MEDICINE AT THE MEDICAL CONFERENCE AT CANNES.

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The patient died due to suicide by hanging 16 months after surgery. Open versus laparoscopic cholecystectomy in acute cholecystitis. To quantify the influence of angiography table height on patient and angiographer irradiation, as compared with other routine protective measures such as the use of protective shields hanging at the tableside and from the ceiling of angiography suites. Based on these results, novel prevention and treatment strategies against A.

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Using a simulation model for plant populations that incorporates demography, mating systems, quantitative genetics, and pollinators, we show that Allee effects can potentially be overcome by transient hybridization with a resident species or an earlier colonizer. Ventricular ectopic activity, which is pronounced in the first 30 min post-ligation period in this model, was also significantly decreased by nifedipine and niludipine (10 and 50 microgram/kg) and by the highest dose (1 mg/kg) of nisoldipine. Radiographically, they may appear as defined radiolucencies, similar to a cyst, or with a ground-glass pattern, similar to a fibro-osseous disease. This paper reviews current literatures combined with our experiences, and elaborates relevant contents in detail. Among the 105 immunity genes, 72 genes showed up-regulated expression levels while 33 showed down-regulation levels.

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At the onset of inflammation, high levels of microglial-derived NO may serve as a cellular defense mechanism helping to clear the damaged tissue and combat infection of the CNS by invading pathogens. and often spreads via lymphatics or through hematogenous metastasis to the brain, bone and adrenal glands. A 7-month-old white baby girl developed hypovolemic shock requiring resuscitation secondary to an air enema reduction of intussusception. Hundred and twenty values were collected in each measuring situation. Histological examinations of kidney showed a delayed penetration with discrete clumps of Y-shaped cells, inflammatory focuses, and compromised tubules and glomerula (Fig.

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One of these patients conceived with the aid of ovulation stimulatory drugs, and the other from in vitro fertilization. Volumetric alterations in the nucleus accumbens and caudate nucleus in bulimia nervosa: a structural magnetic resonance imaging study. The starvation led to a marked decrement of XRE binding in cytosolic fractions 4-36 h later, followed by a robust but transient increment of that in nuclear extracts 12-20 h afterward. Binding of purified hPRR-wTM to renin immobilized onto sensor chips was directly proportional to the hPRR-wTM concentration.

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Type X collagen is a specific product of hypertrophic growth plate chondrocytes and it has been suggested that mutations in the corresponding gene (COL1OA1) may be responsible for certain heritable disorders affecting growth plate cartilage such as the epiphyseal dysplasias. Recently, a low-cost transient imaging system has provided a feasible way to resolve the scene depth, by detecting the reflection instant on the time profile of a surface point. Furthermore, the results of this study are concerning from a skin cancer prevention perspective as the playground areas where children spend the majority of their time (the main play equipment and stand-alone equipment) were considerably less shaded than the eating areas. The importance of TAMs in colorectal liver metastases (CLM) is unknown.

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Uveitis, cataract, vitreitis, cystoid macular edema, epiretinal membrane, and disc edema may occur in patients with immune recovery syndrome (IRS). Non-nociceptive environmental stress induces hyperalgesia, not analgesia, in pain and opioid-experienced rats.

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Recognition of multiple information of human auricular points by linear model It was shown that the diphenol form capable of interacting with free radicals exerts antioxidant effects. Thus dynamic MR study was found to be a useful method for differentiating the tumor from the surrounding nontumorous tissue with decreased portal blood flow.

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D-prime analyses in both experiments suggest that attention is shifted in a discrete manner between locations. The research, which was a case study of a Claybank Private Hospital in Gweru, Zimbabwe, adopted a qualitative approach with a triangulation of data from interviews, observations and analysis of maternal records. In the primary culture characteristic multinucleated giant cells and mononuclear cells were coexisted. The application of a criminal defense of intoxication depends upon the nature of the crime the defendant is accused.

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globosa strain had low expression of all studied virulence factors. It is possible that serum kinetics of PSA are related to tumor cell kinetics but such relationships remain speculative. Of the eligible studies, 7 were validated in a PD patient population only, whilst 40 were tested in both PD and healthy control groups.

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Selected and amplified binding site (SAAB)-imprinting assays and gel mobility shift assays prompted three conclusions. Air pollution effects on the gut microbiota: a link between exposure and inflammatory disease. Single-molecule biophysics has been serving biology for more than two decades.

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Second trimester losses seem to exhibit a stronger negative impact than early losses. To evaluate the mechanism of oxidative stress at glucose levels accompanying diabetic pregnancy.

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Effects of prophylactic vitamin administration on psychoemotional stress tolerance of senior schoolchildren Identification of Meliatoxins in Melia azedarach Extracts Using Mass Spectrometry for Quality Control. Host-parasite coevolutionary histories can differ among multiple groups of parasites associated with the same group of hosts. COL-3 is the second tetracycline derivative to be implicated in the development of drug-induced lupus. The more favorable clinical, pulmonary, and inflammatory responses to an ICS than to an LTRA provide pediatric-based group evidence to support ICSs as the preferred first-line therapy for mild-to-moderate persistent asthma in children.

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The necessary resources, infrastructure, and technological expertise, together with the need for repeated screenings at regular intervals, make cytologic screening difficult to implement in poor countries. These results elaborate a broad profile of microglial genes whose expression is altered by conditions associated with both neurodegenerative diseases and microglial activation.

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Dysfunctional coping in headache: avoidance and endurance is not associated with chronic forms of headache. Expression of COUP-TF correlates with the known expression sites of the arrestin gene in vivo, notably during the differentiation of the retina. This not only relieved the target symptoms, but also those of his Gilles de la Tourette syndrome. Bone metastasis from primary splenic angiosarcoma to the sacrum demonstrated by Tc-99m-labeled red blood cell and Tc-99m MDP bone scintigraphy.

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Three thousand six hundred and twenty-nine cases of DCIS were entered by 274 breast surgeons between January 1998 and December 2004. Contextual influences on the development of obesity in children: a case study of UK South Asian communities.

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The total T3 values were constantly low, whereas the measurement of free T3 by the Amerlex analogue method deviated from the expected only at the time of maximal antibody levels. At discharge, differences in readiness existed between the younger and older old. Afternoon shade events promoted hypocotyl growth, while morning shade was ineffective. Technic and indications for smoothing plastic treatment in dermatology (presentation of material and patients) In our case, the fracture united and the patient returned to all his normal daily activities by 7 weeks postoperatively.

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The data were analyzed by using logistic regression and ROC curve. A review of cases of patients with VWS that attended the cleft lip and palate clinic at the LUTH Idi-Araba, Lagos, from January 2007 to December 2012 was conducted. The hypothesis was that the patients suffering from binge eating disorder would have more cognitive distortions. In this clinical case, we report a patient who experienced cerebellar mutism after undergoing a posterior fossa surgery.

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In this study, superporous hydrogels of poly(vinyl alcohol) and poly(vinyl pyrrolidone) were prepared using a novel technique consisting of a double topico acyclovir ointment emulsion process. As fish eaters bottlenose dolphins (Tursiops truncatus) in human care need to receive daily vitamin supplementation, because whole thawed fish lacks certain vitamins. The protruding premaxilla and minimal median alveolar cleft: an unusual problem with a 12-year follow-up. In the present study we evaluated the efficacy of RCN-NA constructs by both intradermal (ID) and intranasal (IN) routes.

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Our data show that the interaction with Tem1 is important for the function of Cdc15 and that Cdc15 and Tem1 function in a complex to direct the exit from mitosis. If the precio ulcratex 40 mg risk of a family having HNPCC can be identified/asessed, then only the high risk fraction of the population would undergo intensive screening.

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The Salzburg concept of intraoperative radiotherapy for breast cancer: results and considerations. Once formed, remaining aggregates are found to consolidate to form more tightly packed bodies, typically reducing in cross-sectional area by one third. Here diazepam pill images for topiramate we have used flow cytometric analysis of transfectants expressing individual members of the CEA subgroup as an alternative approach to determine the specificities of 13 MAbs. Proinflammatory cytokine levels were increased in the plasma of both n-3 PUFA-deficient and n-3 PUFA-balanced mice. Progressive scoliosis and respiratory in sufficiency often develop once wheelchair dependency occurs.

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In a test of the hypothesis that the de novo induction of vitellogenesis in male X. Five patients with spinal schwannoma located at a minimum of 1-5 mm from the spinal cord were treated with RTRT. A multicenter, randomized, split-face clinical trial evaluating the efficacy and safety of chromophore gel-assisted norfloxacin 400 mg dosierung blue light phototherapy for the treatment of acne.

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A short glossary is included for those readers less familiar with current health service developments in the UK. When ECs were stimulated, 13-HODE was no longer detectable, either in or outside the ECs, and the VnR was detected on the apical surface of the ECs. These results revealed that overexpressing HsfA1a had positive effects on tolerance to rotec tablets side effects diverse stressors by promoting inducible Hsp expression following stress-induced HsfA1a activation.

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Coincidence imaging of positron emitters is achieved using a pair of curved detector banks. Efficacy of using biseptol dosage for dogs mean arterial blood pressure sequence for linear modeling of cerebral autoregulation.

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In these patients, resection of the obstructing segment and uretero-ureterostomy were carried out. Adjuvant chemotherapy with paclitaxel noracin information assurance and carboplatin in non-endometrioid carcinoma of the uterus.

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Further, the two splice variants are differentially distributed. Bands representing Prevotella and Faecalibacterium, which were found in identical positions of the cefzon dosage of amoxicillin DGGE gels originating from human and HMA rat faecal samples, originated from completely identical sequences, indicating that the same strains of these species were dominating in the human and rat samples.