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Identification of microRNAome in rat bladder reveals miR-1949 as a potential inducer of bladder cancer following spinal cord injury. A total of 323 consecutive patients from a single institution who had clinical stage II or III rectal cancer and underwent a long-course neoadjuvant CRT, followed by curative surgery, between 2005 and 2013 were included.

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Anticoagulants, mainly low molecular weight heparins, could prolong survival in cancer patients, particularly in patients with lung cancer, beyond prevention of thromboembolic events. This inhibition was observed even if it was added to the culture medium immediately before the Na125I addition.

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Concentrations of branched chain amino acids, triglycerides and ether phospholipids were increased in mutation carriers with hypertrophy as compared to controls and non-hypertrophic mutation carriers, and correlated with echocardiographic LVH and signs of diastolic and systolic dysfunction in subjects with the MYBPC3-Q1061X mutation. Management of recurrent urethral strictures with covered retrievable expandable nitinol stents: long-term results.

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Discrete temporal solitons along a chain of nonlinear coupled microcavities embedded in photonic crystals. While the endogenous substrates of protein splicing are specific essential proteins found in intein-containing host organisms, inteins are also functional in exogenous contexts and can be used to chemically manipulate virtually any polypeptide backbone.

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Furthermore, screening programs to identify hormonally active chemicals (such as the Endocrine Disruptor Screening Program) may be premature in view of the complexity of the mechanisms involved. The results indicate that most of the dopamine in the superior cervical ganglion and in the locus coeruleus occurs in the cell body region of noradrenaline neurons, whereas only a minor part of the dopamine in the superior cervical ganglion is present in SIF cells. When we compared the ability of these distinct electrophiles to stimulate GSH and HO-1 production, the cyclopentenone electrophiles were somewhat more potent than HNE.

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In vivo Arf pull down assay demonstrated that IQ-ArfGEF/BRAG1 activated Arf6 more potently than Arf1. We investigated differences in 3-dimensional (3D) scapular motions assessed using an optical tracking system between RTSA treated shoulders and asymptomatic contralateral shoulders during arm motion. A total of 67 nests of Centris tarsata were obtained from wood trap-nests of different diameters, consisting of a linear series of brood cells built with sand mixed with oil.

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VEGF-C and its receptor FLT-4 play an important role in the lymphatic metastasis of laryngeal and hypopharyngeal squamous cell carcinoma. When asked questions they considered off topic, likely to reveal sensitive information, or that could lead to changes in their lifestyle, some were silent or answered evasively.

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Occasionally, labeled boutons were observed which definitely did not belong to the type that is generally considered to be of cortical origin. To those with low MCV and MCH in high-risk region, thalassemia should be suspected. Human giardiasis: correlation of specific secretory IgA levels in duodenal fluid to the severity of disease and infestation by Giardia lamblia. The outcomes measured included a seizure occurring within one week of trauma (early seizure), seizure occurring later than one week post-trauma (late seizure), mortality and any adverse events. This article shows the radiological findings observed in three different cases of paraxial hemimelia occurred in goats (radial agenesia, absence of the portion of the distal epiphysis of the radius and anomalous radius with ulnar hypoplasia).

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We conducted whole-genome sequencing (WGS) on six patients with severe early-onset epilepsy who had previously been refractory to molecular diagnosis, and their parents. Biotic and abiotic factors have been proposed to explain patterns of reproductive character displacement, but which factor is most important to character displacement of acoustic signals is not clear. Newer CLL treatment regimens incorporating purine nucleoside analogues and monoclonal antibodies have increased the rate of molecular complete remissions, which may lead to better survival times. The theoretical plate number on averaging all the sample peaks was significantly decreased from 283,000 to 19,000/m. Coronary autoregulation and optimal myocardial oxygen utilization.

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Developing traditional chinese medicine in the era of evidence-based medicine: current evidences and challenges. Functional walking in paralyzed patients by means of electrical stimulation.

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The pedigree disequilibrium test (PDT) (Am J Hum Genet 67:146-154, 2000) can use full genotype information from general (possibly extended) pedigrees with one or multiple affected siblings but requires parental genotypes or genotypes of unaffected siblings. South Asian men have similarly high CAC burden as White men, but higher CAC than other racial/ethnic groups. Our results showed that, while methylation profiles provide a further basis for segregation of certain (Inflammatory and Goblet-like) finer-grained expression-based subtypes, they also suggest that other finer-grained subtypes are not distinctive and can be considered as a single subtype. Strip-till has been used at a large scale in east central Kansas as an alternative to earlier planting dates under a no-till system. The PVE-corrected SUVMEAN (pvcSUVMEAN) was also calculated using (18)F-FDG PET/CT and CECT images.

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Most of those children usually have a normal anal sphincter allowing construction of a neobladder from the rectum, so they are continent without an abdominal stoma, and do not require frequent catheterization, which greatly contribute to a favorable body image. Remote ischemic preconditioning is effective in decreasing liver necrosis in a rat model of ischemia-reperfusion. The performance of the proposed method was tested on two proof-of-concept model systems: the determination of the target peptide in two sets of peptide digests mixtures and the quantification of melamine and metronidazole in two sets of milk powder samples. Accumulation of basic data in human aging and health are essential to the practice of preventive medicine and health support. This pilot study confirmed the safety of oil-based skin treatments during radiation therapy and suggests a trend for reduced skin toxicity for patients receiving emu oil.

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Our approach introduces a new concept for classifying building blocks of proteins based on thermal fluctuations. Reaction of benzoxasilocines with aromatic aldehydes: Synthesis of homopterocarpans. Platinum-based concurrent chemoradiotherapy for tumors of the head and neck and the esophagus. The DDS data do not support the hypothesis that exposure to thimerosal during childhood is a primary cause of autism.

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Systemic corticosteroids are first line treatment, but other options should be considered if systemic symptoms are observed or in case of refractory clinical situation. Genetic varibility among the pathogenic strains may seriously affect its proper diagnostics. The fungal 18S DNA levels were also higher in psoriatic patients than in controls, but the differences were not significant. Activin, a member of the transforming growth factor-beta superfamily, affords neuroprotection in acute brain injury, but its physiological functions in normal adult brain are largely unknown.

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One single, fast and robust capillary electrophoresis method for the direct quantification of intact adenovirus particles in upstream and downstream processing samples. Triton X-100 and osmium tetroxide fixation distorted the fine network structure. The ion-optical prototype of the low energy neutral atom sensor of the Interstellar Boundary Explorer Mission (IBEX).

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Teaching patient-centered interviewing skills to medical students can be challenging. While its roles in innate immunity are well-documented, its function in adaptive immunity is less characterized.

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Antigen extracted from throat swabs of children who were positive for beta-hemolytic plaques (other than group-A streptococci) as seen on blood agar culture gave negative readings, thereby confirming the specificity of the assay for APS. From January 2010 to January 2011, 133 consecutive patients with single and primary ureteral stones were prospectively enrolled. We discuss the situations in which one method or another might be most appropriate. Activities of ALP, ALT, and GLDH, concentrations of sodium, potassium and albumin, and sodium-to-potassium ratio and albumin-to-globulin ratio were significantly lower, and AST activity was significantly higher in animals with DFTD when compared to clinically healthy animals. The management of postoperative pain in thoracic surgery is an open issue.

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Observational registry with 1-year follow-up, performed by a representative, randomly selected sample of 781 primary-care physicians in Germany. The stability of interleukin 6 (IL-6), its soluble receptor (sIL-6R), IL-10 and CC16 or uteroglobin (an endogenous cytokine inhibitor) in human serum was examined using an accelerated stability testing protocol according to the Arrhenius equation. Trace magnetic susceptibility artifact, similar to artifact from a column of air, paralleled the stent. The method was applied to plasma samples of burn patients, and only small volumes of plasma were required for the simultaneous determination of those antimicrobial agents.

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The chronic statin therapy exerts beneficial effects both on systemic and coronary endothelial function in hypercholesterolemic patients with cardiac syndrome X. However, exercises in the fitness studio and moderate strength training are also admissible provided that consideration is given to contraindications and warning signals.

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We also review the potential relationship between centrolobular fatty change and pivoxil-containing antibiotics, which was prescribed for sinusitis before admission. Sri Lanka Clinical Trials registry: www.slctr.lk, SLCTR/2013/006. Multi-component diffusion characterization of radiation-induced white matter damage. Late complications of displaced thoracolumbar fusion instrumentation presenting as new pain in individuals with spinal cord injury.

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Most often keratoglobus is a congenital disease, but it may be secondarily acquired. These beams not only reveal a potentially useful approach to coherent optical wave generation, but also may find applications in remote sensing. Finally we will provide an update on clinical trials on this therapy.

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Getting Hot Under the CALR: What Drives Pediatric Myeloproliferative Neoplasms? Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor.

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The two epitopes recognized by the antibodies are distinct and noninteracting: antibody 2B5 binds to native cytochrome c near a type II turn (residue 44) while antibody 5F8 binds on the opposite face of the protein near the amino terminus of an alpha-helical segment (residue 60). Morphology of ganglion cells which project to the dorsal lateral geniculate and superior colliculus in the ground squirrel.

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To identify potential target genes of miR-330-3p in NSCLC, the miRNA target prediction databases were used. Using the reportable infectious disease database linked to the landed immigration database and several provincial administrative databases, we assembled a cohort of all reported cases of HCV in Quebec, Canada (1998-2008). The radical resection rate for tumor involving important vessel may be improved with the help of vascular technique. Data were collected from 127 subjects with objective cognitive disorders who visited the Alzheimer Centre of the VU Medical Centre in Amsterdam, the Netherlands, in the period from 1 January 2001 to 31 December 2003 with an onset of complaints before the age of 65. Effect of pathological myopia on biomechanical properties: a study by ocular response analyzer.

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To study the neuroprotective effect of the methylene chloride fraction from modified Boyang-Hwan-o-Tang (mBHT-MC), especially against neuronal apoptosis. The indirect and double-labelling immunoperoxidase techniques were used to localize the C5b-9 neoantigens, S-protein and macrophage immunoreactive deposits in myocardial areas with necrosis and sclerosis. In tomographical anatomy the so called supportive ligaments of the uterus are only composed of the round ligaments and the sacrouterine ligaments. Investigation of the HLA component involved in rheumatoid arthritis (RA) by using the marker association-segregation chi-square (MASC) method: rejection of the unifying-shared-epitope hypothesis. Modeling studies showed that the residues Y227 and N229 are buried in the protein core, fixing the loop to other structural elements participating at the bottom of the luciferin binding site.

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Bilateral laparoscopic nephrectomy for significantly enlarged polycystic kidneys: a technique to optimize outcome in the largest of specimens. Use of the unlabelled peroxidase-antiperoxidase method of Sternberger revealed a rather widespread and differential distribution of reaction products resembling human (hPRL) and ovine (oPRL) prolactin.

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HDL-C and adiponectin were measured in the full cohort and in a subgroup, HDL subfractions were obtained by ultracentrifugation, and LPL and hepatic lipase were measured in postheparin plasma. This study shows that the AES-C measures more than one dimension. Furthermore, we conducted power analysis of the proposed method and two conventional methods under various simulated conditions of sample size and distribution of trait frequency. We assessed (1) the relationship between dyadic coping and relationship functioning in couples coping with cancer and (2) whether intervention studies aimed at improving dyadic coping were able to enhance the relationship functioning of these couples. This may be due to lower ventilation rates (i.e., lower SO2 dose rates) and/or to lower airway reactivity in the COPD group.

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Efficacy of the treatment of patients with protracted rheumatism with quinolines We then generated random CCP signatures of various sizes and found sets of 10-15 genes had robust performance in these BL and LUAD cohorts, a finding that was confirmed in an independent cohort.

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Corneal Changes in Children after Unilateral Cataract Surgery in the Infant Aphakia Treatment Study. In cultured sympathetic neurons, CNTF and LIF induce transcription of the VIP and other neuropeptide genes as part of a program of differentiation.

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A simple method for measurement of ureteric peristaltic function in vivo and the effects of drugs acting on ion channels applied from the ureter lumen in anesthetized rats. The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice.

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Cyclotrons, radionuclides, precursors, and demands for routine versus research compounds. Instead, a consistent relation was found between childhood headache (regardless of headache diagnosis in adulthood) and lower scores on most cognitive measures from age 3 years through adolescence (verbal and performance IQ, receptive language, and reading scores).