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Spirotone (Spironolactone)

Spirotone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spirotone is used to treat heart failure, high blood pressure (hypertension), or hypokalemia (low potassium levels in the blood). Spirotone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. Spirotone is also used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body.

Other names for this medication:
Spironolactone, Aldactone, Aldactazide, Aldactazine, Aldazida, Aldazide, Aldozone, Alexan, Alizar, Carpiaton, Espirone, Espironolactona, Expal, Kespirona, Lanx, Letonal, Osiren, Osyrol, Practon, Prilactone, Spiractin, Spiresis, Spirix, Spiroctan, Spirolang, Spirolon, Spiron, Spirono, Spironolacton, Spironolactona, Spironolakton, Spironolattone, Spirotone, Verospiron, Xenalon,

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SWOT analysis of program design and implementation: a case study on the reduction of maternal mortality in Afghanistan. Droplet microfluidics offers significant advantages for performing high-throughput screens and sensitive assays. Additional information on experimental results can be found on our web site. The ANRS CO-8 APROCO-COPILOTE cohort study enrolled 1,281 individuals at the initiation of a protease-inhibitor-containing regimen between 1997 and 1999.

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Cumulative effect of solar ultraviolet-B radiation on pollen germination and tube growth of 19 species in vitro Furthermore, it was possible in rats to trace gradations between normal fibrocytes and sarcoma cells in marginal areas of tumors induced subcutaneously by 3-methylcholanthrene (MCA). We recently proposed an adaptive filtering method for removing ocular artifacts from EEG recordings. We propose the use of heat shock protein-peptide complexes (HSPPCs) to address this challenge.

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Functional analysis of the role of Fur in the virulence of Pseudomonas syringae pv. There were no obvious signs of bone resorption or loss of osseointegration in any of the dogs. In this report, we show that Nup154 interacts genetically and physically with Cup, a germline-specific protein implicated in multiple aspects of female gametogenesis, including the regulation of the nurse-cell chromosome structure. The results demonstrated that there are some distinct differences between youth and adult pitching mechanics.

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Promotion of viral internal ribosomal entry site-mediated translation under amino acid starvation. The method allows for the detection of melamine, ammeline, and ammelide at approximately 5 microg g(-1), and cyanuric acid at approximately 90 microg g(-1) in wheat flour. The prognostic factors (age, stage, grading, histological type, performance status and residual disease), have been evaluated through an actuarial analysis of survival and compared with those reported by many authors in literature. Overactivity of CMA can be associated with tubular lysosomal pathology and certain cancers.

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The NPS antithrombotics programme appears to have had modest success, but such evaluations raise questions about whether a focus on outcomes at a national level is appropriate, given likely concealment of effects at local levels. Human sex-determination system is at least doubly driven: by sex-chromosomes and by sex-hormones.

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Our goal is to provide a performance comparison of state-of-the-art multi-label learning algorithms for the analysis of multivariate sequential clinical data from medical records of patients affected by chronic diseases. Urodynamic assessment was performed in 52 patients with urinary symptoms positively diagnosed as suffering from multiple sclerosis. We sought to translate this purification tactic into a powerful tool for the isolation of natural products and demonstrate that chemoselective enrichment can reduce the number of purification steps required and increase the yield obtained for important natural products, as compared to the use of traditional chromatography methods alone. Ambroxol could protect rats from pneumonia by improving the level of endogenous PS, especially DPPC. Control of pH by a buffering system or an ion-exchange device is a necessity if the liquid storage shall be possible for more than 5--6 weeks.

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The neurosphere assay is traditionally used for the post-hoc identification of stem cells, primarily due to the lack of definitive markers with which they can be isolated from primary tissue and has the major advantage of giving a quick estimate of precursor cell numbers in brain tissue derived from individual animals. Synechococcus ferredoxin could also be immobilized on a Toyopearl gel and repeatedly used in an automated high-performance liquid chromatographic system.

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All chemicals tested induced a dose-dependent increase in MN and a delay in cell-cycle progression. Result of an endoscopic mucosal resection demonstrated at the International Gastric Cancer Congress in New York. Optimal results can be achieved through use of the appropriate surgical technique. Pattern Recognition Receptors in Cancer Progression and Metastasis. Hopefully it will decrease the mortality of patients with acute stroke.

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Macrodactyly or megalodactyly is a rare congenital malformation of essentially unknown etiology. Our hypothesis is that electronic signatures of DNA acquired as a molecule translocates through a nanopore would be significantly different for methylated and nonmethylated bases. The purinergic P2X3 receptor (P2X3R) expressed in the dorsal root ganglion (DRG) sensory neuron and the P2X7 receptor (P2X7R) expressed in the surrounding satellite glial cell (SGC) are two major receptors participating in neuron-SGC communication in adult DRGs.

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Subclass mapping: identifying common subtypes in independent disease data sets. The results showed that the sequence possessed great similarity to one fragment of the 17th chromosome in the genome.

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A significant increase in MT-1/2 concentration was detected in the urine of LEC rats with age and especially at the hepatitis stage. A handheld flow genetic analysis system (FGAS): towards rapid, sensitive, quantitative and multiplex molecular diagnosis at the point-of-care level. This paper presents the design and analysis of a handheld manipulator for vitreoretinal microsurgery and other biomedical applications.

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The effect of varying solvents for MoS2 treatment on its catalytic efficiencies for HER and ORR. Usefulness of urinary ferritin measurement in the detection of intravascular hemolysis. An updated checklist of Korean hippoboscids consisting of seven genera (Hippobosca L., Icosta Speiser, Lipoptena Nitzsch, Ornithoica Rondani, Ornithoctona Speiser, Ornithomya Lattreille, and Ornithophila Rondani) and 11 species is presented, including hosts, collection records, and repositories. The finding of an inverse association between birthweight and triglycerides in both sexes and of inverse associations between birthweight and total and LDL-cholesterol only in women suggests that the mechanisms underlying the associations with birthweight may vary for different lipids. The herpes simplex and varicella-zoster viruses are members of the subfamily alpha herpesviruses with specific properties of the virion and with the capacity to establish latent infections in humans.

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Ten patients with absence of function in one labyrinth were exposed to caloric and rotatory stimulation several times during the compensating period of 8 weeks. We show that mutations in ISY1 cause lethality in the absence of Ntc20p, and that the double mutant isy1Delta syf2Delta shows a temperature-dependent cell cycle arrest.

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The results demonstrated that the number of nucleolar silver stained granules decreased after the inhibition of the nucleolar RNA synthesis with these drugs disregarding the mode of their action. It is known that the transient receptor potential vanilloid receptor-1 (TRPV1) is an important mediator of CGRP and SP release.

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The IMiDs have been reported to have a multitude of activities, including anti-angiogenic, cytotoxic, and immunomodulatory. To investigate the influence of exercise and major competition on infectious episodes in athletes with spinal cord injuries (SCI). Preparation of Bi-Based Ternary Oxide Photoanodes BiVO4, Bi2WO6, and Bi2Mo3O12 Using Dendritic Bi Metal Electrodes.

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In vivo experiments showed a mild radiosensitizing effect of dCK overexpression both in the Gl261 and C6 models. Characterization of glucocerebrosidase in peripheral blood cells and cultured blastoid cells. fowleri cultures, containing amoeba antigens, also failed to cause proliferation of mouse spleen lymphocytes. Renal blood flow was evaluated by color and spectral Doppler ultrasound at 1 h and 24 h post-I/R.

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The diagnostic yield is high and the procedure appears to be relatively safe. Scanning electron microscopy was used to examine morphological changes in the cochlea after treatment and to detect degenerative changes in the auditory hairs of the basal turn. Heart failure is characterized by increased ventilation during exercise, which is positively related to increased peripheral and central chemoreceptor sensitivity.

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Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction. An additional experiment was carried out to investigate in human subjects walking on a treadmill, the alteration to the energy expenditure as a result of positive and negative tractive loads applied at waist level through a rope parallel to the plane of the treadmill.

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Adiponectin is an anti-inflammatory adipokine that is present in serum in a range of multimeric forms that appear to have different metabolic functions. In this study, alcohol consumption, wine drinking, and wine and spirits preference among women were associated with a higher number of teeth compared with abstainers. Even more difficult is achieving a vascularized bone flap closure of such bony defects. The cytotoxicity of 1-(1-phenylalkylideneamino)-2,4-azetidinediones and their mode of action in human and murine tumor cells. The purpose was to determine the seroprevalence of HIV-1 and HTLV I-II in patients undergoing ED resuscitations, the magnitude of health care worker exposure, and risk factors associated with infection.

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All patients with cystic fibrosis who produce purulent sputum are potential candidates for dornase alfa therapy. Interestingly, this effect is inhibited by the application of a 15 aa peptide representing the alternatively spliced start of exon 6. Paclitaxel is an effective antineoplastic agent originally extracted in low yield from the bark of Taxus brevifolia. The radiographic findings in 39 patients with acquired immunodeficiency syndrome (AIDS) were reviewed.

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Kikuchi-Fujimoto disease associated with systemic lupus erythematosus. Also, it appears that excess proline is transported to the vacuole in an ATP-independent manner.

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Localization of midgut-specific protein antigens from Aedes aegypti (Diptera: Culicidae) using monoclonal antibodies. Study C investigated the pharmacokinetics of onercept following repeat subcutaneous administration of six doses of 50mg every 48 hours in 12 subjects. This allowed the identification both of useful information and the best way that this information could be presented. Serum laminin (P1 fragment) and type IV collagen levels were determined in patients with hepatic disorders.

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The aim of this study was to compare the outcome after stabilization of the dislocated posterolateral tibia fragment using either closed reduction and screw fixation, or open reduction and plate fixation via the posterolateral approach in complex ankle fractures. Combination treatment with interferon and ribavirin for chronic hepatitis C.

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Voriconazole mixed in fly food significantly protected flies infected with F. OTOF mutations revealed by genetic analysis of hearing loss families including a potential temperature sensitive auditory neuropathy allele. ISG15 is an interferon-stimulated, linear di-ubiquitin-like protein, with anti-viral activity.

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Preferences on vital and nonvital tooth bleaching: a survey among dentists from a city of southern Brazil. The oil was analyzed by gas chromatography (GC) and chromatography/mass spectrophotometry (GC/MS). Effects of longitudinal baffles on particles settling in a sedimentation basin. After assignment to either single or divided attention conditions, 44 ecstasy/polydrug users and 48 non-users were presented with 80 word pairs at encoding. The subjects, 21 healthy young men, conducted the maneuver against expiratory pressures of 20, 30, and 40 mm Hg, each lasting 30 s, at body positions of vertical, horizontal, and 6 degrees head down tilt (HDT).

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We observed, in our typical clinical ECT sample of 37 patients, a significant and synergistic influence of tcpO2/tcpCO2 on seizure quality. The compositional surface chemistry was determined from a truly quantitative IR (ATR geometry) study in the range of 900-4000 cm(-)(1). Clinical laboratories need to have adequate funding, equipment, and expertise to provide a rapid and clinically relevant antibiotic testing service in centers where these resistance mechanisms are encountered. A theoretical and non-destructive experimental approach for direct inclusion of measured collagen orientation and recruitment into mechanical models of the artery wall.

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In the first of two studies, all night sleep records for six individuals were each staged twice by each of two qualified electroencephalographers. The Biplane-DTS can provide a good estimate of the peak skin dose and cumulative skin dose distribution during biplane neurointerventional procedures. This paper contains a collection of data concerning different holders of medical, especially pharmacological functions in ancient Rome and a discussion of their social status.

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When these male rats were allocated to either a high or low baseline PPI group, 0.5 mg kg(-1) 8-OH-DPAT disrupted PPI in the high baseline group only. Efforts are made to define the exposures to potential toxicants, assess the associated risks, and reduce the uncertainties. ST changes during sodium nitroprusside therapy in acute myocardial infarction.

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Helicobacter pylori colonizes the human stomach and induces the activation of inflammatory cytokines, including interleukin (IL)-8, in the gastric mucosa. This article examines a number of areas of disagreement surrounding antimicrobial susceptibility testing and discusses some of the useful susceptibility testing techniques for which no standardized procedures have been established.

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To review the pharmacology, electrophysiology, and toxicity of amiodarone and to discuss the clinical results produced when amiodarone is used as therapy for patients with atrial fibrillation, patients with nonsustained ventricular tachycardia and cardiomyopathy, patients who have recently had myocardial infarctions, and patients who have survived out-of-hospital cardiac arrest caused by ventricular tachycardia or ventricular fibrillation. While OS is not affected, an association was seen with higher NRM in our study. The short-time dynamic properties of colloidal particles in quasi-two-dimensional geometries are studied by digital video microscopy. The formation of defects in the graphene matrix, which bend the carbon plane, requires that two or more graphene embryos with significantly different growth axis merge.

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More recently, another equally, if not more, important scheme of regulation of gene expression, called epigenetics, has emerged to explain the many biological observations that traditional genetic mechanisms have failed to decipher. The present study aimed at finding out demographic, clinical, personality, and behavioural correlates of age at onset of alcohol dependence. The results were in good agreement with experimental reports for normal joint, vastus lateralis and vastus medialis relieved.

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In this article, the authors discuss briefly the leptospirosis, emphasizing mainly the pulmonary form of disease. Examination of the wall structure of the above algae suggest a relationship between the presence of sporopollenin and the development of an outer, trilaminar wall component. The SSRs performed better at clustering germplasm into populations than did a set of 847 SNPs or 554 SNP haplotypes, and SSRs provided more resolution in measuring genetic distance based on allele-sharing.

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The aim of this study was to evaluate the prognostic significance of cardiac troponins in CCLI patients who had no clinical evidence of unstable coronary heart disease. Each enzyme antirobe 150 mg side effects suppresses the catalytic activity of Src family kinases by phosphorylating their C-terminal negative regulatory tyrosine residues. This suggests that in addition to the mechanism of the topoisomerase II involving DNA breakages, other mechanisms of action, such as the radical mechanism or the direct adduct formation of the ortho-quinone with DNA or protein, may also involve and account for the apparent KB cytotoxicity. Titrations of this haemoglobin with CO show that at high pH the molecule is highly co-operative (Hill coefficient 2.8) whereas at low pH the titration data can best be described as the sum of contributions from non-co-operating subunits of different affinity. Metacarpophalangeal pattern profile (MCPP) was determined on 38 Prader-Willi syndrome individuals and compared with a previous report on 16 patients.

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Effect of the anticarcinogenic drug 6-mercaptopurine on mineral metabolism in the mouse. Under arthroscopic control, a guidewire is introduced through the anterior portal in between the anterior labrum and anterior femoral head cartilage and into the central compartment. The objective of this study was terazosin hydrochloride anhydrous calcium to escalate radiation therapy to a tumoricidal hypofractionated dose without exceeding the maximally tolerated dose (MTD) in patients with locally advanced NSCLC. TAG1-PCD was designed by considering the reactivity, hydrophilicity, and cationic nature that is required to yield a stable gold conjugate in aqueous media.