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Symasteride (Finasteride)

Symasteride works by inhibiting type II 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone (DHT). This converted form of testosterone stimulates development of the penis, testes and scrotum, as well as other male sexual characteristics such as body hair and pubic hair. DHT also promotes growth of the prostate. In 1992, Symasteride 5 mg per day was approved by the U.S. Food and Drug Administration (FDA) as a treatment for benign prostatic hyperplasia. The agent was marketed by Merck under the name Symasteride. Patients need to allow at least 6 months for the therapeutic effects to be determined. Symptoms that may improve include difficulty urinating, increased urination frequency and decreased urinary flow. If the therapy is discontinued, symptoms will return within around 6 to 8 months. In 1997, Symasteride 1 mg per day was approved by the FDA as a treatment for male pattern baldness and this time the agent was market by Merck as Symasteride. Symasteride 1 mg per day was shown to benefit men with mild to moderate hair loss in a five-year study. Two thirds of the men who took the medication on a daily basis saw some regrowth of their hair, while those who did not take the medication experienced further hair loss. Analysis showed that for all five years of the study, the average hair count remained above baseline among the Symasteride group and was increased compared to those who did not take the treatment. The medication is only effective for as long as it is used, with the therapeutic effects being lost within 6 to 12 months after discontinuation of the therapy.

Other names for this medication:
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Virus titers were maximal by 24 h and peaked at approximately 10(5) pfu/mL. However, the inhibition of an automatic activity (Stroop test) and the formation of a memory trace (Buschke memory test) were disturbed in both young and older women.

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Motor function was assessed using a Motor Performance Test (MPT), with a set of six tasks exploring lower extremity performance (LEP): rising once from a chair, turning in a half circle, tandem walking, standing on one leg, stair climbing, and walking 5 m. Varicella zoster-associated retinal and central nervous system vasculitis in a patient with multiple sclerosis treated with natalizumab. However, lymphocytes failed to proliferate in response to allo-stimulation by renal epithelial cells. Exocrine pancreatic secretions in pigs as influenced by the source of carbohydrate in the diet. Weighted density functional theory of spherically inhomogeneous hard spheres.

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Bioactive magnetic near Infra-Red fluorescent core-shell iron oxide/human serum albumin nanoparticles for controlled release of growth factors for augmentation of human mesenchymal stem cell growth and differentiation. Most important, partial cleavage of the carbohydrate chains of LPS is caused on radioiodination by the procedure described. The effect of trauma, in the form of intraperitoneal injections or puncture of the orbital venous plexus, on peripheral white blood cell count in rats. Retinopathy of prematurity appears to be accompanied by increased retinal blood flow.

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The lesions were included 3 cases of cen encephalocele, 2 of cerebrospinal rhinorrhea and one of left retrobulbar tumor. These applications add important physiologic information to the anatomic information readily available from conventional echocardiography.

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We compare three general classes of dispersion mechanisms, which encompass 11 different dispersion methods, and we have dispersed long SWCNTs, short multi-wall carbon nanotubes, and short SWCNTs in order to understand the most appropriate dispersion methods for the different types of CNTs. In the second phase of diagnosis are further neurophysiological investigations, which are only indicated in more special circumstances. The present article attempts to standardize OPS nomenclature, indications, and reconstruction choice selection embedded in a thorough review of the literature. Their study reveals that three subunits of Pol I perform functions in transcription elongation that are outsourced to the transcription factors TFIIF and TFIIS in the analogous Pol II transcription system. It was found that pretreatment with pirenperone caused a parallel shift to the right of the dose-effect curve of LSD.

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We used western blot to detect NLRP3 inflammasome activation and the expression of thioredoxin binding protein (TXNIP), DCFH-DA to investigate intracellular reactive oxygen species (ROS), flow cytometry to analyze apoptosis. Bone biopsy was performed because of the diagnostic doubt between diabetes and infectious osteoarthropathy. While substitution does affect the lifetime, the size of the substituent has only a minor effect.

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We now report the successful establishment of a first resistant strain, designated A.LRA. A new experimental approach for studying bacterial genomic island evolution identifies island genes with bacterial host-specific expression patterns. The interaction of edeine with the small subunit indicates its role in inhibiting initiation and shows its involvement with P-site tRNA. Next, GW803430 was evaluated on alcohol self-administration in protracted abstinence induced by IA in high-drinking rats.

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The current study aimed at investigating the mediation effects of plasma 5-HT on cigarette smoking-induced COPD and the relation between plasma 5-HT levels and age. Pontobulbar palsy and sensorineural deafness (Brown-Vialetto-van Laere syndrome): A case from Northwest Iran. A study of individual differences and of interaction in the behaviour of some aspects of language in interviews.

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Glyphosate application also increased the amino acid concentrations, with the exception of arginine, of broomrape growing on common vetch and did not generally influence concentrations in leaves or roots of common vetch. Paramagnetic NMR of Phenolic Oxime Copper Complexes: A Joint Experimental and Density Functional Study. The 250-kDa AKAP known as gravin plays a central role in organizing G-protein-coupled receptors to the protein kinases and phosphatases that regulate receptor function in desensitization, resensitization, and sequestration. The in vivo incorporation of mannose, retinol and mevalonic acid into phospholipids of hamster liver.

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This promotes the development of tools to help clinicians in the diagnosis. Economic development and urbanization of cities favor a shift of etiological agents from anthroponoses to zoonoses in contemporary China.

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A study with a pure enantiomeric target was carried out to assess the degree of stereo-specific imprinting for injection of racemic mixtures. Our study was unable to show significant differences in magnesium and citrate urinary outputs between controls and patient groups. To understand the mechanism of sequestration in the microvasculature of patients with falciparum malaria, we examined the patterns of expression of mRNAs for adhesion molecules (ICAM-1, VCAM-1, and E-selectin) and tight junction molecules (occludin, vinculin, and ZO-1) in human umbilical vein endothelial cells (HUVECs) co-cultured with Plasmodium falciparum-parasitized red blood cells (PRBCs) in vitro. The need for use information will further be dependent on the analysis of costs (of gathering data) versus benefits (increase in quality of the assessment). Serological markers of hepatitis A, B and C viruses in rural communities of the semiarid Brazilian northeast.

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commersonii, AtCBF1 activity also mimicked cold treatment by increasing proline and total sugar contents in the absence of cold. A subcutaneous abscess is registered 10 days after hospitalization.

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This study aims to understand the mechanisms underlying altered phosphorylation of myofilament proteins in heart failure. These results indicate that HIV infection of B twins occurs predominantly in utero, whereas infection of A twins (and, by implication, singletons) occurs predominantly intrapartum.

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Cap43 and Mina53 are both considered to be important biological and prognostic factors in neuroblastoma. We have used this technology to assay the functional activation of GPCRs coupled to different signaling pathways and have compared it to standard assays. Using a panel of observers, ICDAS scores on teeth or photographs were evaluated against the histological gold standard. Using audio computer-assisted self-interviewing, 398 women from 5 to 23 weeks of gestation at an urban hospital described steps and reasons that could have led to a delayed abortion.

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The effect of doxazosin on recruitment of Fas-associated death domain (FADD) and procaspase-8 to the Fas receptor was examined via analysis of death-inducing signaling complex formation. Partial purification and properties of the hemolysin from Rhodophyllus rhodopolius: examination on the condition of the hemolysis Anesthesiologists completed an anonymous survey of their use of spinal and epidural techniques in adult patients undergoing cardiac surgery.

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Clinical experience with a once-daily, extended-release formulation of diltiazem in the treatment of hypertension. The tick has been found feeding primarily on brown pelicans, Pelecanus occidentalis, but also has been found on the laughing gull, Larus atricilla, and the American oystercatcher, Haematopus palliatus. Based on our findings, we proposed several candidate genes that might be used to improve salt tolerance in upland cotton. There have been reports of rippled pattern in trichoblastomas, sebaceomas, and basal cell carcinomas. Synergy between inflammation, hypoxia, and 5-ASA to increase H2O2 production could explain how 5-ASA supports innate defense, although potentially increasing the burden of DNA damage.

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The bizarre larvae of Leptobrachella mjobergi are fossorial and live in the gravel beds of small streams. Some bacterial infections such as Clostridium and Vibrio are associated with hemolysis.

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Here, we offer a model of team functioning relevant to polytrauma and outline a team training program to improve services. Aspirin resistance could be determined by: bleeding time, optical aggregometry, PFA-100 (Platelet Function Analyzer), Ultegra-RPFA (Rapid Platelet Function Assay), activated aggregation time, whole blood aggregometry, platelet aggregate ratio, flow cytometry, measurements of platelet surface proteins and blood or urine thromboxane B2 levels. Effects of health and safety problem recognition on small business facility investment. Choosing to use primary facilities, health centres and clinics, particularly when consultations are carried out by general practitioners (GPs), is more beneficial than choosing between public and private providers. Analyses of variance for repeated measures were used to analyze health behaviors, coronary risk factors, and psychosocial factors at baseline and 3 months.

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The level of the above changes appears to be directly related to the CEF strength. In both oxidation states, the synchronous formation of the Schiff base linkages in heme a and a(3) relies on the structural communication between the two hemes via the H-bonding network involving R438 and R439 and the propionate groups of the two hemes as well as the helix X housing the two proximal ligands, H378 and H376, of the hemes. A second-order rate constant for the activation of the tyrosine kinase could be calculated from the time courses. EEG coherence analysis detects changes in regions known to be involved in visual processing and executive functions. It was elaborated on the base of Doss method with some modifications.

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Apoptotic cells were quantified by annexin V-FITC-propidium iodide double staining. Such a signal could be an error related potential which indicates when the decoder did not classify correctly. This combined approach using silenced cells and a series of human DLBCL samples leads us to a better understanding of the role of BCL6 as an NFkappaB regulator in B-cells. Tear breakup time, Schirmer testing with and without anesthesia, rose bengal staining, central corneal sensitivity, nucleus-to-cytoplasmic ratio, and goblet cell density were evaluated 2 weeks before and 1 week, 3 months, and 9 months after surgery.

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In a prospective study of 124 neonates born to mothers with normal pregnancy and pregnancy associated hypertension (PAH), serum IgG, IgA and IgM were estimated by single radial immunodiffusion technique. Traditionally, studies of affect have used stimuli characterized along either affective dimensions or discrete emotional categories, but much current research draws on both of these perspectives. We have examined four biopsies of cervical and vulvar tissue, each with evidence of infection by two different HPVs. Metabolic preconditioning protects BSEP/ABCB11-/- mice against cholestatic liver injury.

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We develop a statistical mechanics framework where it is possible to get information about the most relevant observables given a large spectrum of linear and nonlinear constraints including those depending both on the number of multiedges per link and their binary projection. From April 2004 to March 2013, 53 consecutive patients were treated with EGFR-TKIs at our department.

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In this study, we used high-speed video of 51 hops from five cane toads (Bufo marinus) to test the hypothesis that forelimb kinematics change predictably with distance. Strategies for laboratory and field experiments are outlined that would quantify power supplies, power demands, and habitability.

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The effects of a new antihypertensive agent, troxonium tosylate, were studied in a group of 22 patients whose ages ranged from 48 to 88 years. We have studied thicker films than previously reported and have found no deviations in the film structure from the earlier findings.

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Systemic Treatment of Recalcitrant Pediatric Psoriasis: A Case Series and Literature Review. A polyurethane-coated platinum electrode with a 1-mm bare tip for measurement of blood flow and a guide cannula made of stainless steel tube for naloxone injection were implanted chronically into the brain. Relationship of blood pressure and flow during CPR to chest compression amplitude: evidence for an effective compression threshold.

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Thus, statins seem to have a favourable effect on heat release from atherosclerotic plaques, and whether this effect has an impact on plaque stabilization needs to be investigated in future studies. In order to test the validity of the assumptions concerning motility, we injected a tumor cell line with low motility in vitro and a subline of the same tumor cell line with high motility in vitro into the thigh of syngeneic rats. Adiponectinemia, inflammatory process activity, and endothelial dysfunction in patients with type 2 diabetes and acute coronary syndrome with ST elevation in relation to the severity of lesions in the coronary arteries Core outcome measures for exercise studies in people with multiple sclerosis: recommendations from a multidisciplinary consensus meeting. Due to low yields, ChIP assays of transcription factors generally require amplification of immunoprecipitated genomic DNA.

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The concentrations of these hydrophobic organic contaminants (HOCs) in fish and in sediment organic carbon were correlated with HOCs accumulation in triolein-SPMDs. The results provide the first demonstration for altered ingestive behavior in an animal model of liver disease and suggest that the bile duct ligated rat may be useful in studying mechanisms of chemosensory disturbances in human liver disease. Uncontrolled subsurface evaporite dissolution could lead to hazards such as land subsidence. The enzyme removes a COOH-terminal dipeptide resulting in the sequence NP(147-155), which is identical to the naturally processed peptide. Nocturnal Hypertension (NH) is an independent risk factor for cardiovascular morbidity and mortality (M-M).

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Purification and partial characterization of the constituent proteinases. In the 30 years, since the discovery of nucleocytoplasmic glycosylation, O-GlcNAc has been implicated in regulating cellular processes as diverse as protein folding, localization, degradation, activity, post-translational modifications, and interactions. In the inferior colliculus (IC), most terminal boutons on labeled corticotectal fibers were of large size. Effect of smoking on neonatal and maternal serum and breast milk leptin levels.

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Monoclonal antibody AG-1 initiates platelet activation by a pathway dependent on glycoprotein IIb-IIIa and extracellular calcium. Epiarachnoid spaces around the root sleeves were also sealed to ensure complete resolution of the CSF leakage. The following two parameters were examined: the interpeak latency difference between wave I and wave V (IPL I-V) at each stimulus rate, and the increase in IPL I-V (delta IPL I-V) when the stimulus rate was increased from 9.5 Hz. Interestingly, when cells were pretreated with IGFBP-3, prior to the simultaneous addition of IGFs and IGFBP-3, the inhibitory effect was higher for IGF-I than for IGF-II.

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In addition, compounds 3 and 9 revealed inhibitory effects on lipopolysaccharide-stimulated nitric oxide production, and compounds 1, 3 and 9 displayed hypolipidaemic effects in in vitro bioassays. The latter was characterized by a diffuse, granular localization of rabbit gamma-globulin and complement in most glomeruli and by electron-dense deposits in the subepithelial zone of the glomerular capillary walls, suggesting that these glomerular changes are induced by the localization of antigen-antibody complexes. Breast cancer in pregnancy is rare with an incidence of 1:3,000 to 1:10,000 and is the second most common after cervical cancer. In a prospective randomized study, 50 patients with pressure ulcers were divided into 2 groups: Control group received standard wound care and the study group was treated with LTAPP once every week for 8 consecutive weeks in addition to standard wound care.

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Rule-based category learning in children: the role of age and executive functioning. Congenital aneurysm of the right anterior sinus of Valsalva (interventricular aneurysm) with spontaneous rupture into the left ventricle. Should bedside sonography be used first to diagnose pneumothorax secondary to blunt trauma?

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Residual vesicles could be visualized on the surface of the inner acrosomal membrane of spermatozoa that had undergone the acrosome reaction. In this report we show that the 68 kDa calmodulin-specific binding protein in HeLa cells is tightly associated with the DNA polymerase alpha-primase component of the 21S complex of enzymes for DNA synthesis. Cultured CUMC-3 cells produced human chorionic gonadotropin beta-subunit and tumor antigen of squamous cell carcinoma (TA-4). These findings show the potential of studying cloned membrane proteins in oocytes for both their surface topography and their structure-function relationship in native membrane without the need for crystallization. aeruginosa competitiveness in the aerobic region, consistent with in vitro experimental studies.

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In situ hybridization and image analysis of retrogradely labeled facial motor neurons indicated that such a cold block induced T alpha 1 alpha-tubulin and p75 NGF receptor mRNAs to the same level as did a corresponding nerve transection. Mycotoxic effect on fetal development: pine needle abortion in mice. These foci appeared to correspond to the reported two cortical areas, where two different types of rhythmical jaw movements were induced by repetitive electrical stimulation (Jap. Such changes may be of adaptive importance during times of drought.

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RFCA is an effective and curative therapy for ventricular arrhythmia originating from ventricular outflow tract. Rapid thin-layer chromatography of various weak analgesics in saliva.

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For each sample, blood was divided in vitro into four subgroups: control without priming, priming alone with cytochalasin B (CytoB), priming plus stimulation with platelet-activating factor (PAF), and priming plus stimulation with N-formyl-methionyl-leucyl-phenylalanine (fMLP). Both methods showed that the changes in blood perfusion induced by the hydralazine were significant, and that the differences between the results for the two drug doses were not significantly different. Potential research questions as well as issues in research design, measurement, data collection, and analysis are discussed.

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In looking forward, several strategies are emerging to circumvent these limitations and improve conformal radiosurgery. Rapid advances in mechanistic understanding of the disease, improved imaging methods, and innovative biomarkers now provide an opportunity to define PH phenotypes on the basis of biomarkers, advanced imaging, and pathobiology. After excluding organicity, the possibility of psychogenic mechanisms should be borne in mind. Heterogeneity in surface glycoproteins of mouse peritoneal macrophage populations.

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Interleukin 1alpha genotypes were determined from blood samples by standard methods. Acoustic communication is prominent in adult anuran amphibians, in reproductive, territorial and defensive contexts. This region, named processing determinant domain, functions as a signal for protein processing in the context of not only Gli2 and Gli3 cefuroxime axetil 500 mg tabs in html protein sequences but also a heterologous hybrid protein, which would otherwise be completely degraded by the proteasome.

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Although the frequency of DNA double-strand breaks (DSBs) appears moderately reduced in Atasy3-1, the main recombination defect is a reduction in the formation of COs. During sensory ombitasvir manufacturer representative experience, the retina transmits a diverse array of signals to the brain, which must be parsed to generate meaningful percepts that can guide decisions and actions. However, there is still room for improvement, and preventive programs can become more effective when specific parameters are targeted, such as adequate conditioning of players in the preseason.

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Fibroblast growth factor 2 promotes microvessel formation from mouse embryonic aorta. Using the evolutionary information zival forte wheels of native structures can significantly improve the quality of designed sequences.

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Argininosuccinate synthetase activity was measured in amniotic fluid cells cultured from 25 normal fetuses and from 2 fetuses vitamin a ad3e mod de administrare augmentin at risk for citrullinemia. Using repetitive transcranial magnetic stimulation (rTMS), we first tested whether perturbing one area would disrupt behavior. Abundant anastomoses, multiplicated ways for outflow from every layer, manifested interactions between the venous plexuses are specific for the intraorganic venous bed of the urinary bladder. These data suggest that obese and overweight children are indeed more responsive to food promotion, which specifically stimulates the intake of energy-dense snacks.

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This study demonstrated that SPARC antagonizes bufalin-induced apoptosis via inhibition of the intrinsic apoptosis pathway, inhibition of quetiapine contraceptive pill cell cycle arrest and activation of certain pathways involved in proliferation. Lack of association between HLA-A, -B and -DRB1 alleles and the development of SARS: a cohort of 95 SARS-recovered individuals in a population of Guangdong, southern China.

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However, it has recently been demonstrated that BRAT directly binds to RNA. salmonicida (AS) following injection vaccination with commercial vaccines containing formalin-killed bacteria, but the protection is often suboptimal under Danish mariculture conditions. VEP acuity, FPL acuity, and visual behavior of visually impaired children. Removal of cholesterol inhibited stromal cell-derived factor-1alpha- and macrophage inflammatory protein 1beta-induced chemotaxis omeprazole magnesium delayed-release capsules of both PBL and HOS cells expressing CD4 and coreceptors.

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Evaluation of Tongue Cancer Using High-Resolution Sonography: Comparison With Magnetic Resonance Imaging. However, metastatic spread was dramatically suppressed when cotransfected cells injected into nude mice were omeprazole seeds in india pretreated with the invasive BPAC. Swabs were plated onto enriched selective media and non-selective media. Review article: the extra-skeletal effects of vitamin D in chronic hepatitis C infection.

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In contrast, the cause of beta 3Gal-T deficiency appears to be different in Jurkat T cells. To evaluate the possible relationship of optic tine helene valle omag online disc area with retina nerve fiber layer in different glaucoma subtypes.

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To demonstrate an association between saprophytic fungal infections occurring at the bronchial anastomosis (BA) and the development of additional complications arising at this site. Occlusion roentgenography in traumatic lesions of the norfloxacin mepha 400 erfahrungen nasal skeleton emaculata may involve various defense pathways as indicated by transcript profiling of defense related genes.